DNA’s ‘topography’ influences where cancer-causing mutations appear

DNA’s 3D shape — its twisted ladders complexly curled into coils and loops — and other features beyond its genetic code may influence where “hotspots” of cancer-causing mutations accumulate.

That’s according to a new study of how “genomic topography” affects cancer mutations. Genomic topography broadly refers to elements of the genome beyond the sequence of molecules that make up DNA. That includes variations in how tightly our DNA is wound and which genes are “activated” in different cells. 


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